INTR10

Day 1 - Wednesday, September 10

14:00- 19:00
Registration and poster mounting

19:00
Welcome address, introduction, and reception

Day 2 - Thursday, September 11

08:00-09:00
PLENARY LECTURE I
Roger Barker (Cambridge, UK)
Can cell therapies really ever help treat Parkinson’s disease?

Session I: Parkinson’s disease: experimental models and clinical applications
Chairmen: Patrick Brundin and Harold Robertson

09:00
Stephen Dunnett (Cardiff, UK)
Getting cells ready for clinical transplantation

09:20
Ivar Mendez (Halifax, Canada)
Clinical neural transplantation for Parkinson’s disease: Methodological considerations

09:40
Ole Isacson (Boston, USA)
Dopamine neurons transplanted into Parkinson’s disease patients survive for up to 14 years without signs of pathology

10:00
Jia-Yi Li (Lund, Sweden)
Long-term surviving transplanted dopamine neurons exhibit alpha-synuclein accumulation and Lewy bodies in Parkinson patients

10:20-10:40 Break

10:40
Christian Winkler (Freiburg, Germany)
Dopamine-dependent dykskinesia: Role of dopaminergic and serotonergic transplants

11:00
Manolo Carta (Lund, Sweden)
Serotonin autoreceptor agonists for the treatment of L-DOPA-induced dyskinesia: towards clinical investigation

11:20
Jürgen Winkler (Regensburg, Germany)
Reduced neurogenesis in models of Parkinson´s disease

11:40
Morton Meyer (Odense, Denmark)
Dopaminergic differentiation of human neural stem cells: Effects of Bcl-XL and oxygen tension

12:00-14:00 Poster Session including lunch & art and industrial exhibition

Session II: Parkinson’s and Alzheimer’s disease
Chairman: Klaus Unsicker

14:00
Greg Stewart (Minneapolis, USA)
The unravelling of cell therapy for Parkinson´s disease: Where do we go from here…why gene therapy trials should be listening…and why didn´t we learn from trophic factors?

14:20
Armin Blesch (La Jolla, USA)
Nerve growth factor (NGF) gene therapy for Alzheimer’s disease - An update

14:40
Elliot Mufson (Chicago, USA)
Cholinotrophic dysfunction during the progression of Alzheimer´s disease

15:00
Nora Abrous (Bordeaux, France)
Adult hippocampal neurogenesis and spatial memory

15:20-15:40 Break

15:40-16:40
PLENARY LECTURE II
Bernhard Landwehrmeyer (Ulm, Germany)
Huntington’s disease - Clinical applications of restorative and regenerative approaches - A neurologist´s perspective

Session III: Huntington’s disease
Chairman: Bernhard Landwehrmeyer

16:40
Paola Piccini (London, UK)
Recent functional imaging in Huntington’ s disease

17:00
Máté Döbrössy (Freiburg, Germany)
Environmental and experience-dependent graft plasticity and functional recovery in a rodent HD model

17:20
Gregor Wenning (Innsbruck, Austria)
Towards neurotransplantation in MSA: preclinical evidence

17:40 Free evening

Day 3 - Friday, September 12

08:00-09:00
PLENARY LECTURE III
Jeffrey Kordower (Chicago, USA)
Gene therapy for movements disorders

Session IV: Gene therapy and neuroplasticity
Chairmen: Wolfgang Driever and John Yu

09:00
Deniz Kirik (Lund, Sweden)
PET imaging demonstrates correlation between correction of dopamine neurotransmission and behavioural recovery following gene therapy

09:20
Bernard Schneider (Lausanne, Switzerland)
Viral vectors for modelling and treating Parkinson´s disease

09:40
Stephane Palfi (Creteil, France)
A phase I/II clinical trial for Parkinson’s disease using ProSavin®, a lentiviral vector delivering the genes for dopamine biosynthesis

10:00-10:20 Break

10:20
Jacqueline Sagen (Miami, USA)
Transplantation of cells engineered for enhanced delivery of analgesics

10:40
Michael Kaplitt (New York, USA)
Normalization of motor deficits following AAV-mediated XIAP gene therapy in a mouse model of Huntington’s disease

11:00-12:00
PLENARY LECTURE IV
Evan Snyder (La Jolla, USA)
The homeostatic pressure exerted by stem cells in degenerative or injured CNS environments

12:00-14:00
Poster Session including lunch & art and industrial exhibition

Session V: Mechanisms of Brain Repair and Stroke
Chairman: Isao Date

14:00
Lotta Granholm (Charleston, USA)
Food for thought: Would you have thought it?

14:20
Shinn-Zong Lin (Taichung, Taiwan)
Stem cell therapy in stroke patients: clinical trials

14:40
Moussa Youdim (Haifa, Israel)
Neurorestorative activities of Rasagline and multifunctional drug M30; The involvement of tyrosine kinase receptor activation and inhibition of cell cycle

15:00
Zaal Kokaia (Lund, Sweden)
Neural stem cells for the cell therapy of stroke damaged brain

15:20
Demeral Liu (Taichung, Taiwan)
Upregulation of SDF-1/CXCR4 promotes neuroplasticity through enhancing PrPC-mediated neuritogenesis in hOEC/ONF-implanted stroke model

15:40-16:00 Break

16:00-18:00 Poster Session & art and industrial exhibition

19:00 Conference Dinner

Day 4 - Saturday, September 13

08:00-09:00
PLENARY LECTURE V
Anders Björklund (Lund, Sweden)
Generation of dopamine neurons from embryonic stem cells for transplantation in Parkinson´s disease

Session VI: Stem cells
Chairmen: Kerstin Krieglstein and Alexander Storch

09:00
Oliver Brüstle (Bonn, Germany)
Pluripotent sources of functional neurons

09:20
Roy Bakay (Chicago, USA)
Therapeutic use of human embryonic stem cells (hESC) and human umbilical cord blood (hUCB) stem cells in Parkinson’s disease model

09:40
Ernest Arenas (Stockholm, Sweden)
Wnt5a, a key pro-differentiation factor that reduces tumor formation and enhances the engraftment of stem cell-derived DA neurons

10:00
Uwe Himmelreich (Leuven, Belgium)
Multimodal stem cell imaging

10:20
Jens Clausen (Tübingen, Germany)
Ethical aspects of regenerative medicine in neurodegenerative disorders

10:40-11:00 Break

Session VII: Spinal Cord injury
Chairman: Norbert Weidner

11:00
Antal Nogradi (Szeged, Hungary)
Transplantation of embryonic motoneurones into the injured spinal cord: Replacement or rescue of host motoneurons?

11:20
Henrich Cheng (Taipe, Taiwan)
Repair of the chronic spinal cord injury: Result of phase II clinical trial

11:40
Fanie Barnabé-Heider (Stockholm, Sweden
Identification and characterization of stem/progenitor cells upon spinal cord injury

12:00
Olivier Raineteau (Zürich, Switzerland)
Manipulating bHLH proteins to promote neural precursor cells differentiation

12:20 Concluding remarks

12:40 Lunch