Authors:
Stewart, GR
Institutions:
Medtronic Neuromodulation, Minneapolis, MN 55432
Title of abstract : The Unraveling of Cell Therapy for Parkinson’s Disease: Where do we go from here . . . why gene therapy trials should be listening . . . and why didn’t we learn from trophic factors?
Abstract text:
Starting in the early 1990s, biotechnology brought great [...]
Authors:
Wenning GK, Koellensperger M, Stefanova N
Institutions:
Department of Neurology
University Hospital
Anichstrasse 35
6020 Innsbruck
AUSTRIA
Title of abstract : Towards neurotransplantation in MSA: preclinical evidence
Abstract text:
Multiple system atrophy (MSA) is a fatal degenerative disorder characterized by a unique oligodendrogliopathy with cytoplasmic alpha-synuclein inclusions and secondary neuronal loss affecting striatonigral and olivopontocerebellar projections as well as central autonomic nuclei. MSA [...]
Authors:
Winkler, Juergen
Institutions:
Section Molecular Neurology
University Erlangen
Germany
Title of abstract : Reduced neurogenesis in models of Parkinson disease
Abstract text:
Neurogenesis persists in the adult mammalian brain. One of the most exciting ideas for repair is that one might be able to harness the adult brain’s endogenous capacity for cell renewal. To stimulate adult neurogenesis, we choose a dopamine receptor [...]
Authors:
M. Anderova 1,3
I. Prajerova1,2
P. Honsa 1
and A. Chvatal 1-3
Institutions:
1 Department of Cellular Neurophysiology - Laboratory of Neurobiology, Inst. Exp. Med., ASCR;
2 Dept. Neurosci. and
3 Center for Cell Therapy and Tissue Repair 2nd Medical Faculty, Charles University; Prague, Czech Republic
Title of abstract : The role of Sonic hedgehog and Wnt-7a in neural stem cell differentiation in [...]
Authors:
Garcia J, Hahn M, Timmer M, Papazoglou A, Nikkhah G
Institutions:
Dept. of Stereotactic Neurosurgery, Laboratory of Molecular Neurosurgery, Neurocentre, University Hospital Freiburg. Breisacher Str. 64, 79106 Freiburg, Germany
Title of abstract : Distinctive pattern of anatomical maturation and functional integration of dopaminergic progenitor cells following transplantation in a rat model of Parkinson’s disease
Abstract text:
The restorative capacity of [...]
Authors:
Papazoglou A, Jiang W, Diaconu O, Büchele F, Kohn-Cordeiro K, Döbrössy MD, Nikkhah G
Institutions:
Department of Stereotactic Neurosurgery, Laboratory of Molecular Neurosurgery,
Neurocentre, University Hospital Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany
Title of abstract : The influence of pellet density on the graft-induced functional recovery in a skilled paw-reaching test in the rodent unilateral 6-OHDA Parkinson’s disease [...]
Authors:
Dunnett SB 1
Brundin P 2
Mendez I 3
Rosser AE 1
Institutions:
1 Cardiff University, Cardiff, UK
2 Lund University, Lund, Sweden
3 Dalhousie University, Halifax, Canada
Title of abstract : Getting cells ready for clinical transplantation
Abstract text:
Taking cells to clinical trial involves a range of challenges over and above the biological issues of cell survival, integration and function addressed in experimental [...]
Authors:
Europe: Li J-Y 1, Englund E 2, Holton JL 3, Soulet D 1, Hagell P 4, Lees AJ 3, Lashley T 3, Quinn NP 5, Rehncrona S 6, Bjoörklund A 7, Widner H 4, Revesz T 3,9, Lindvall O 4,8,9 and Brundin P 1, 9
USA: Kordower JH 1, Chu Y 1, Hauser RA 2, Freeman [...]
Authors:
Ernest Arenas
Institutions:
Laboratory of Molecular Neurobiology, MBB, CEDB, Karolinska Institute, Stockholm, Sweden.
Title of abstract : Wnt5a, a key pro-differentiation factor that reduces tumor formation and enhances the engraftment of stem cell-derived DA neurons
Abstract text:
Wnt5a is a morphogen that activates the Wnt/planar cell polarity (PCP) pathway and serves multiple functions during development. We previously found that Wnt5a [...]
Authors:
Wessolleck J 1*, Klein A 1,2*, Papazoglou A 1, Metz GA 2 and Nikkhah G 1
* These authors contributed equally to this work.
Institutions:
1 Laboratory of Molecular Neurosurgery, Dept. of Stereotactic Neurosurgery, University Hospital – Neurocentre, Breisacher Str. 64, D-79106 Freiburg, Germany
2 Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K [...]
