INTR10

Authors:

Winkler C

Institutions:

Department of Neurology, University of Freiburg, Freiburg, Germany

Title of abstract : Dopamine-dependent dyskinesia: Role of dopaminergic and serotonergic transplants

Abstract text:

Transplantation of fetal ventral mesencephalic tissue in Parkinson’s disease has given variable results. While some patients have shown substantial recovery in motor function, others have shown no improvement and even a worsening of dyskinesia. Recent experimental studies have shown that two types of dyskinesia may have to be considered in transplanted patients: L-DOPA-induced dyskinesia (LID) and graft-induced dyskinesia (GID). The graft composition concerning dopamine and serotonin neurons appears to be relevant for the change of LID after transplantation. While LID is reduced by transplants containing sufficient numbers of dopamine cells, transplants of serotonin cells only will worsen LID. However, serotonin neurons appear to be detrimental primarily in cases when the number of dopamine cells within the graft is low in combination with severe damage of the host dopamine system. In such cases, animals with dopamine-denervating lesions that are non-dyskinetic despite repeated L-DOPA-administration, may even turn dyskinetic due to a serotonin transplant. In contrast to LID, grafts of serotonin neurons have so far not been shown to induce or worsen GID. Rather, the number and placement of dopamine cells within the target region may be one of the critical factors suggesting that an even reinnervation of the target region using sufficient numbers of dopamine cells may help to avoid this graft-induced side effect.

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