01-07-08(16:22:47)
Authors:
T.Kadota,
T.Yasuhara, A.Kondo, N.Tajiri, F.Wang,
H.Liang, Y.Miyoshi, I.Date
Institutions:
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Title of abstract : Continuous infusion of erythropoietin has neuroprotective effects of traumatic brain injury model of rats
Abstract text:
Traumatic brain injury (TBI) remains a major health problem and despite developing recent researches, no effective therapy is available to repair biostructural damage following the injury. To develop an effective therapy for TBI, many researches focusing on endogenous neuroplasticity using cell therapy or pharmacotherapy. Erythropoietin (EPO) is one of the hopeful molecules demonstrating neuroprotective potencies to cerebral ischemia. In our study, the therapeutic effects of EPO was explored using TBI model of rats. Injury was induced by impacting the left cerebral cortex with a fluid percussion device, measured 3-4 atm. EPO (100 U/day) or rat serum albumin as a control was administered into the ventricle from 24 hours before brain injury and lasted for 7 days with subsequent euthanasia for immunohistochemincal evaluations to reveal the amelioration of neuronal damage, inflammatory reaction and apoptotic cell death, as well as behavioral deteriorations. The behavioral and immunohistochemical evaluations revealed neuroprotective effects of EPO on TBI model of rats and thus suggesting that clinical application of EPO might be considered after demonstrating the safety and underlying mechanisms.
