29-06-08(19:01:23)
Authors:
Tajiri N., Yasuhara T., Kondo A., Yuan W., Kadota T., Wang FF., Baba T., Liang HB., Miyoshi Y., Date I.
Institutions:
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Title of abstract : Exercise has neuroprotective and neurorestorative effects on Parkinson’s disease model of rats
Abstract text:
Recent studies demonstrates that rehabilitation ameliorates physical and cognitive impairments of patients with stroke, spinal cord injury, and other neurological diseases and that rehabilitation also has potencies to modulate brain plasticity. Here we examined the effects of compulsive exercise on Parkinson’s disease model of rats.
Before 6-hydroxydopamine (6-OHDA, 20μg)-lesion into the right striatum of female SD rats, bromodeoxyuridine (BrdU) was injected to label the proliferating cells. Subsequently, at 24 hours after the lesion, the rats were forced to run on the treadmill (11m/min, for 30 minutes/day, 5 days/week). As behavioral evaluations, cylinder test was performed every week and amphetamine-induced rotational test was performed at 2 and 4 weeks with consequent euthanasia for immunohistochemical investigations.
The exercise group showed a significantly better behavioral recovery in cylinder test and significant decrease in the number of amphetamine-induced rotations. Correspondingly, a significant preservation of tyrosine hydroxylase (TH)-positive fibers in the striatum and TH-positive neurons in the substantia nigra pars compacta (SNc) was demonstrated, compared to the control group. Additionaly, the number of migrated BrdU- and Doublecortin-positive cells toward the lesioned striatum were increased in the exercise group.
The results suggest that exercise improves deteriorated motor function and exerts neuroprotective effects or enhance the neuronal differentiation in Parkinson’s disease model of rats.
