INTR10

Authors:

Yasuhara T, Tajiri N, Wang FF, Agari T, Kondo A, Kadota T, Yuan WJ, Liang H, Baba T, Miyoshi Y, Date I

Institutions:

Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Title of abstract : Effects of rehabilitation upon neurogenesis

Abstract text:

Background
Rehabilitation is an important therapy for patients with functional impairment induced by the central nervous system disorders. We explored the effects of rehabilitation upon neurogenesis using 2 types of animal models.
Experiment 1
Disuse syndrome model of rats by hindlimb suspension was used to explore the suppressive effects of neurogenesis by lack of exercise. Immunohistological investigations demonstrated the suppression of neurogenesis in the subventricular zone and hippocampus of the model rats and partial recovery by rehabilitation. Additionally, brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) might be involved in neurogenesis in this experiment.
Experiment 2
Therapeutic effects of rehabilitation upon chronic staged Parkinson’s disease model of rats were explored. Two month-rehabilitation using treadmill ameliorated behavioral and immunohistological impairment of rats with enhanced neurogenesis and neural migration. The upregulation of BDNF and glial cell line-derived neurotrophic factor was also clarified in the rats receiving rehabilitation.
Conclusions
Therapeutic effects of rehabilitation might be at least partially mediated by enhanced neurogenesis through upregulated neurotrophic factors. The potencies of rehabilitation should be enlightened for patients with CNS disorders, although further studies revealing underlying mechanisms will be required.

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